No-Tox! + Rewind Ultimate Duo

Botox-Effect, Age-Defying Duo, Regenerative Aesthetics

The powerhouse age-defying duo

The NoTox Rewind Ultimate Duo combines our two most advanced prescription anti-aging formulas for around-the-clock skin rejuvenation.

Rewind Ultimate, our prescription-strength night cream, features Tretinoin, GHK-Cu copper peptide, DMAE, Hyaluronic Acid, and Estriol to stimulate collagen and elastin, smooth fine lines, and restore hydration and firmness while you sleep.
NoTox, your daytime peptide cream, smooths expression lines without injections, using Leuphasyl® and Argireline® to naturally relax wrinkle-forming muscles. DMAE firms, GHK-Cu supports collagen repair, and hyaluronic acid keeps skin deeply hydrated.

Price range: $500.00 through $520.00

Strength

Prescription Type

Clear

Are you purchasing this as a gift for someone else?

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I understand that a consultation is required to confirm eligibility before MyHealth1st can dispense your prescription. Pre-payment acts as a deposit on your account unless you already have an active prescription, in which case we will process your refill. If a consultation is needed, our office will contact you to schedule. *

Details

Primary Function: Around-the-clock anti-aging system delivering wrinkle smoothing, firming, and collagen support day and night.

Key Active Ingredients:
NoTox - Leuphasyl: 3% / Argireline: 3% / GHK-Cu: 0.2% / HA: 1% / DMAE: 3% | Rewind Ultimate - GHK-Cu: 0.5% / Tretinoin: 0.033-0.1% / DMAE: 3% / HA: 1.5% / Estriol: 1%

Suggested Use: After cleansing and toning in the morning, apply NoTox to the face and neck, focusing on areas with fine lines or sagging. In the evening, use Rewind Ultimate on face and neck after cleansing and toning.

The Science of 24-Hour Skin Renewal

The No-Tox! + Rewind Ultimate Duo is a comprehensive, around-the-clock system designed to target the two primary drivers of visible skin aging:
repetitive muscle contraction (daytime) and collagen degradation + slowed cellular turnover (nighttime).

By addressing both pathways in a coordinated cycle, this duo supports smoother, firmer, and more resilient skin over time.

Day: Neuro-Modulation + Prevention (No-Tox!)

During the day, skin is exposed to constant movement, environmental stress, and repeated facial expressions that contribute to fine line formation.

No-Tox! utilizes a targeted peptide complex of Argireline® and Leuphasyl® to modulate the signaling pathways responsible for muscle contraction. These peptides work at different points along the neuromuscular pathway to reduce the intensity of acetylcholine-driven contractions—helping to soften expression lines without restricting natural movement.

Supporting actives like DMAE, GHK-Cu, and hyaluronic acid further enhance skin firmness, hydration, and structural integrity throughout the day.

Night: Regeneration + Structural Repair (Rewind Ultimate)

At night, the skin shifts into a repair-focused state—making it the ideal window for deeper regeneration.

Rewind Ultimate leverages prescription-strength tretinoin to accelerate cellular turnover, normalize keratinization, and stimulate collagen synthesis at the dermal level.

This is supported by:

GHK-Cu (Copper Peptide): promotes collagen remodeling and tissue repair
Estriol: supports skin thickness, elasticity, and hydration—particularly in hormonally influenced aging
DMAE + Hyaluronic Acid: enhance firmness, hydration, and barrier support

The result is improved skin texture, elasticity, and long-term structural integrity.

Why the Duo Works Better Together

Most skincare approaches focus on either surface-level smoothing or deep repair—but rarely both in a coordinated way.

This system is intentionally designed to:

Reduce the cause of wrinkles (muscle movement) during the day
Repair the result of that movement (collagen breakdown) at night
Support continuous skin remodeling across a full 24-hour cycle

This dual approach allows for both immediate visible smoothing and progressive, long-term improvement in skin quality.

A Regenerative Alternative to Conventional Aesthetics

Rather than overriding the skin or musculature, this system works with the body’s natural biology—supporting collagen production, cellular renewal, and balanced muscle activity over time.

The result is a more refined, natural appearance:
smoother expression lines, improved firmness, and healthier skin function—without sacrificing movement or expression.

Prescription Disclaimer

A consultation is required to confirm eligibility before we can dispense your prescription. Pre-payment acts as a deposit on your account unless you already have an active prescription, in which case we will process your refill. If a consultation is needed, our office will contact you to schedule.